MCDTR: Methods and Measurement: Disease Modeling Software for Clinical Research


Model development and validation

  • Zhou H, Isaman DJM, Messinger S, Brown MB, Klein R, Brandle M, Herman WH: A Computer Simulation Model of Diabetes Progression, Quality of Life, and Cost. Diabetes Care 28:2856-2863, 2005. [pdf]
  • Ye W, Brandle M, Brown MB, Herman WH, The Michigan Model for Coronary Heart Disease in Type 2 Diabetes: Development and Validation, DIABETES TECHNOLOGY & THERAPEUTICS, Volume 17, Number 11, 2015 [pdf] [supplementary data]
  • Brandle M, Zhou H, Smith BR, et al. The direct medical cost of type 2 diabetes. Diabetes Care 2003;26:2300-4. [pdf]
  • Coffey JT, Brandle M, Zhou H, Marriott D, Burke R, Tabaei BP, Engelgau MM, Kaplan RM, Herman WH: Valuing healthrelated quality of life in diabetes. Diabetes Care 25:2238–2243, 2002 [pdf]

Model application

  • Herman WH, Ye W, Griffin SJ, Simmons RK, Davies MJ, Khunti K, Rutten GE, Sandbaek A, Lauritzen T, Borch-Johnsen K, Brown MB, Wareham NJ. Early Detection and Treatment of Type 2 Diabetes Reduce Cardiovascular Morbidity and Mortality: A Simulation of the Results of the Anglo-Danish-Dutch Study of Intensive Treatment in People With Screen-Detected Diabetes in Primary Care (ADDITION-Europe). Diabetes Care. 2015 May 18. pii: dc142459. [Epub ahead of print] PubMed PMID: 25986661. [pdf][supplementary data]

Statistical methods

  • Isaman DJM, Herman WH Brown MB. A discrete-state and discrete-time model using indirect estimates. Statistics in Medicine 2006; 25: 1035-1049. DOI: 10.1002/sim.2241 [pdf]
  • Isaman DJM, Barhak J, Ye W (2009) Indirect Estimation of a Discrete-State Discrete-time model using Secondary Data Analysis of Regression Data. Statistics in Medicine 28(16):2095-115. [pdf]
  • Ye W, Isaman DJM, Barhak J (2012). Use of Secondary Data to Estimate Instantaneous Model Parameters of Diabetic Heart Disease: Lemonade Method. Information Fusion 13(2): 137-145 [pdf]

Model Software

  • Barhak J, Isaman DJM, Ye W, Donghee Lee (2010). Chronic Disease Modeling and Simulation Software. Journal of Biomedical Informatics 43 (5): 791-799. [PMCID: 20558320] [pdf]