Michigan Diabetes Research Center: MICPC: Imaging: Publications

Representative manuscripts that used the Imaging Laboratory to support their research.

Authors in bold are associated with the MDRC.

2016

“4E-BP2/SH2B1/IRS2 Are Part of a Novel Feedback Loop That Controls β-Cell Mass”
AUTHORS: Blandino-Rosano M, Scheys JO, Jimenez-Palomares M, Barbaresso R, Bender AS, Yanagiya A, Liu M, Rui L, Sonenberg N, Bernal-Mizrachi E.  
PUBLICATION: Diabetes 2016 Aug;65(8):2235-48 doi: 10.2337/db15-1443 Epub 2016 May 23 PMID 27217487 PMCID: PMC4955981.
“Occludin S471 Phosphorylation Contributes to Epithelial Monolayer Maturation”
AUTHORS: Bolinger MT, Ramshekar A, Waldschmidt HV, Larsen SD, Bewley MC, Flanagan JM, Antonetti DA.  
PUBLICATION: Mol Cell Biol 2016 Jul 14;36(15):2051-66 doi: 10.1128/MCB.00053-16 Print 2016 Aug 1 PMID 27185880 PMCID: PMC4946429.
“Noninvasive in vivo imaging of embryonic β-cell development in the anterior chamber of the eye”
AUTHORS: Cras-Méneur C, Elghazi L, Fort P, Bernal-Mizrachi E.  
PUBLICATION: Islets 2016 Mar 3;8(2):35-47 doi: 10.1080/19382014.2016.1148236 PMID 26950054 PMCID: PMC4878273.
“BetaB2-crystallin mutations associated with cataract and glaucoma leads to mitochondrial alterations in lens epithelial cells and retinal neurons”
AUTHORS: Dulle JE, Rübsam A, Garnai SJ, Pawar HS, Fort PE.  
PUBLICATION: Exp Eye Res 2017 Feb;155:85-90 doi: 10.1016/j.exer.2017.01.005 Epub 2017 Jan 26 PMID 28131617.
“Protective Effect of a GLP-1 Analog on Ischemia-Reperfusion Induced Blood-Retinal Barrier Breakdown and Inflammation”
AUTHORS: Gonçalves A, Lin CM, Muthusamy A, Fontes-Ribeiro C, Ambrósio AF, Abcouwer SF, Fernandes R, Antonetti DA.  
PUBLICATION: Invest Ophthalmol Vis Sci 2016 May 1;57(6):2584-92 doi: 10.1167/iovs.15-19006 PMID 27163772 PMCID: PMC4868093.
“Disulfide Mispairing During Proinsulin Folding in the Endoplasmic Reticulum”
AUTHORS: Haataja L, Manickam N, Soliman A, Tsai B, Liu M, Arvan P.  
PUBLICATION: Diabetes 2016 Apr;65(4):1050-60 doi: 10.2337/db15-1345 Epub 2016 Jan 28 PMID 26822090 PMCID: PMC4806660.
“Algorithm for the Measure of Vitreous Hyperreflective Foci in Optical Coherence Tomographic Scans of Patients With Diabetic Macular Edema”
AUTHORS: Korot E, Comer G, Steffens T, Antonetti DA.  
PUBLICATION: JAMA Ophthalmol 2016 Jan;134(1):15-20 doi: 10.1001/jamaophthalmol.2015.3949 PMID 26502148 PMCID: PMC4713241.
“Occludin S490 Phosphorylation Regulates Vascular Endothelial Growth Factor-Induced Retinal Neovascularization”
AUTHORS: Liu X, Dreffs A, Díaz-Coránguez M, Runkle EA, Gardner TW, Chiodo VA, Hauswirth WW, Antonetti DA.  
PUBLICATION: Am J Pathol 2016 Sep;186(9):2486-99 doi: 10.1016/j.ajpath.2016.04.018 Epub 2016 Jul 14 PMID 27423695 PMCID: PMC5012506.
“Lipodystrophy and severe metabolic dysfunction in mice with adipose tissue-specific insulin receptor ablation”
AUTHORS: Qiang G, Whang Kong H, Xu S, Pham HA, Parlee SD, Burr AA, Gil V, Pang J, Hughes A, Gu X, Fantuzzi G, MacDougald OA, Liew CW.  
PUBLICATION: Mol Metab 2016 May 14;5(7):480-90 doi: 10.1016/j.molmet.2016.05.005 eCollection 2016 PMID 27408774 PMCID: PMC4921803.
“Methods for Studying Ciliary Import Mechanisms”
AUTHORS: Takao D, Verhey KJ.  
PUBLICATION: Methods Mol Biol 2016;1454:1-14 doi: 10.1007/978-1-4939-3789-9_1 PMID 27514912.
“Monitoring C-Peptide Storage and Secretion in Islet β-Cells In Vitro and In Vivo”
AUTHORS: Zhu S, Larkin D, Lu S, Inouye C, Haataja L, Anjum A, Kennedy R, Castle D, Arvan P.  
PUBLICATION: Diabetes 2016 Mar;65(3):699-709 doi: 10.2337/db15-1264 Epub 2015 Dec 8 PMID 26647386 PMCID: PMC4764152.

2015

“TRAP-seq defines markers for novel populations of hypothalamic and brainstem LepRb neurons”
AUTHORS: Allison MB, Patterson CM, Krashes MJ, Lowell BB, Myers MG Jr, Olson DP.  
PUBLICATION: Mol Metab 2015 Feb 7;4(4):299-309 doi: 10.1016/j.molmet.2015.01.012 eCollection 2015 Apr PubMed PMID 25830093 PMCID: PMC4354921.
“The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function”
AUTHORS: Carpenter BS, Barry RL, Verhey KJ, Allen BL.  
PUBLICATION: J Cell Sci 2015 Mar 1;128(5):1034-50 doi: 10.1242/jcs.162552 Epub 2015 Jan 14 PubMed PMID 25588831 PMCID: PMC4342584.
“Experimental evaluation and computational modeling of tissue damage from low-flow push-pull perfusion sampling in vivo”
AUTHORS: Cepeda DE, Hains L, Li D, Bull J, Lentz SI, Kennedy RT.  
PUBLICATION: J Neurosci Methods 2015 Mar 15;242:97-105 doi: 10.1016/j.jneumeth.2015.01.019 Epub 2015 Jan 19 Review PubMed PMID 25614385 PMCID: PMC4331210.
“Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability”
AUTHORS: Du Y, Cramer M, Lee CA, Tang J, Muthusamy A, Antonetti DA, Jin H, Palczewski K, Kern TS.  
PUBLICATION: FASEB J 2015 May;29(5):2194-204 doi: 10.1096/fj.14-269431 Epub 2015 Feb 9 PubMed PMID 25667222 PMCID: PMC4415023.
“Rab27A Is Present in Mouse Pancreatic Acinar Cells and Is Required for Digestive Enzyme Secretion”
AUTHORS: Hou Y, Ernst SA, Stuenkel EL, Lentz SI, Williams JA.  
PUBLICATION: PLoS One 2015 May 7;10(5):e0125596 doi: 10.1371/journal.pone.0125596 eCollection 2015 PubMed PMID 25951179 PMCID: PMC4423933.
“The exocyst complex regulates free fatty acid uptake by adipocytes”
AUTHORS: Inoue M, Akama T, Jiang Y, Chun TH.  
PUBLICATION: PLoS One 2015 Mar 13;10(3):e0120289 doi: 10.1371/journal.pone.0120289 eCollection 2015 PubMed PMID 25768116 PMCID: PMC4359155.
“Carboxyl terminus of HSC70-interacting protein (CHIP) down-regulates NF-κB-inducing kinase (NIK) and suppresses NIK-induced liver injury”
AUTHORS: Jiang B, Shen H, Chen Z, Yin L, Zan L, Rui L.  
PUBLICATION: J Biol Chem 2015 May 1;290(18):11704-14 doi: 10.1074/jbc.M114.635086 Epub 2015 Mar 19 PubMed PMID 25792747 PMCID: PMC4416871.
“Conditional expression of Pomc in the Lepr-positive subpopulation of POMC neurons is sufficient for normal energy homeostasis and metabolism”
AUTHORS: Lam DD, Attard CA, Mercer AJ, Myers MG Jr, Rubinstein M, Low MJ.  
PUBLICATION: Endocrinology 2015 Apr;156(4):1292-302 doi: 10.1210/en.2014-1373 Epub 2015 Jan 16 PubMed PMID 25594696 PMCID: PMC4399319.
“Retinylamine Benefits Early Diabetic Retinopathy in Mice”
AUTHORS: Liu H, Tang J, Du Y, Lee CA, Golczak M, Muthusamy A, Antonetti DA, Veenstra AA, Amengual J, Von Lintig J, Palczewski K, Kern TS.  
PUBLICATION: J Biol Chem 2015 Jul 2 pii: jbc.M115.655555 [Epub ahead of print] PubMed PMID 26139608.
“Ventral tegmental area neurotensin signaling links the lateral hypothalamus to locomotor activity and striatal dopamine efflux in male mice”
AUTHORS: Patterson CM, Wong JM, Leinninger GM, Allison MB, Mabrouk OS, Kasper CL, Gonzalez IE, Mackenzie A, Jones JC, Kennedy RT, Myers MG Jr.  
PUBLICATION: Endocrinology 2015 May;156(5):1692-700 doi: 10.1210/en.2014-1986 Epub 2015 Mar 3 PubMed PMID 25734363 PMCID: PMC4398771.
“Transient early food restriction leads to hypothalamic changes in the long-lived crowded litter female mice”
AUTHORS: Sadagurski M, Landeryou T, Cady G, Bartke A, Bernal-Mizrachi E, Miller RA.  
PUBLICATION: Physiol Rep 2015 Apr;3(4) pii: e12379 doi: 10.14814/phy2.12379 PubMed PMID 25907790 PMCID: PMC4425981.
“Three-dimensional spheroid cell model of in vitro adipocyte inflammation”
AUTHORS: Turner PA, Tang Y, Weiss SJ, Janorkar AV.  
PUBLICATION: Tissue Eng Part A 2015 Jun;21(11-12):1837-47 doi: 10.1089/ten.TEA.2014.0531 Epub 2015 Apr 22 PubMed PMID 25781458.

2014

“Maternal diet-induced microRNAs and mTOR underlie β cell dysfunction in offspring”
AUTHORS: Alejandro EU, Gregg B, Wallen T, Kumusoglu D, Meister D, Chen A, Merrins MJ, Satin LS, Liu M, Arvan P, Bernal-Mizrachi E.  
PUBLICATION: J Clin Invest 2014 Oct;124(10):4395-410 doi: 10.1172/JCI74237 Epub 2014 Sep 2 PubMed PMID 25180600 ; PubMed Central PMCID: PMC4191023.
“Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during caloric restriction”
AUTHORS: Cawthorn WP, Scheller EL, Learman BS, Parlee SD, Simon BR, Mori H, Ning X, Bree AJ, Schell B, Broome DT, Soliman SS, DelProposto JL, Lumeng CN, Mitra A, Pandit SV, Gallagher KA, Miller JD, Krishnan V, Hui SK, Bredella MA, Fazeli PK, Klibanski A, Horowitz MC, Rosen CJ, MacDougald OA.  
PUBLICATION: Cell Metab 2014 Aug 5;20(2):368-75 doi: 10.1016/j.cmet.2014.06.003 Epub 2014 Jul 3 PubMed PMID 24998914 PMCID: PMC4126847.
“SH2B1 in β-cells promotes insulin expression and glucose metabolism in mice”
AUTHORS: Chen Z, Morris DL, Jiang L, Liu Y, Rui L.  
PUBLICATION: Mol Endocrinol 2014 May;28(5):696-705 doi: 0.1210/me.2013-1333 Epub 2014 Mar 19 PubMed PMID 24645678 PMCID: PMC4004774.
“The thermogenic effect of leptin is dependent on a distinct population of prolactin-releasing peptide neurons in the dorsomedial hypothalamus”
AUTHORS: Dodd GT, Worth AA, Nunn N, Korpal AK, Bechtold DA, Allison MB, Myers MG Jr, Statnick MA, Luckman SM.  
PUBLICATION: Cell Metab 2014 Oct 7;20(4):639-49 doi: 10.1016/j.cmet.2014.07.022 Epub 2014 Aug 28 PubMed PMID 25176149 PMCID: PMC4192552.
“Leptin-inhibited PBN neurons enhance responses to hypoglycemia in negative energy balance”
AUTHORS: Flak JN, Patterson CM, Garfield AS, D'Agostino G, Goforth PB, Sutton AK, Malec PA, Wong JM, Germani M, Jones JC, Rajala M, Satin L, Rhodes CJ, Olson DP, Kennedy RT, Heisler LK, Myers MG Jr.  
PUBLICATION: Nat Neurosci 2014 Dec;17(12):1744-50 doi: 10.1038/nn.3861 Epub 2014 Nov 10 PubMed PMID 25383904 PMCID: PMC4255234.
“mTORC1-independent reduction of retinal protein synthesis in type 1 diabetes”
AUTHORS: Fort PE, Losiewicz MK, Pennathur S, Jefferson LS, Kimball SR, Abcouwer SF, Gardner TW.  
PUBLICATION: Diabetes 2014 Sep;63(9):3077-90 doi: 10.2337/db14-0235 Epub 2014 Apr 16 PubMed PMID 24740573 PMCID: PMC4141367.
“A parabrachial-hypothalamic holecystokinin neurocircuit controls counterregulatory responses to hypoglycemia”
AUTHORS: Garfield AS, Shah BP, Madara JC, Burke LK, Patterson CM, Flak J, Neve RL, Evans ML, Lowell BB, Myers MG Jr, Heisler LK.  
PUBLICATION: Cell Metab 2014 Dec 2;20(6):1030-7 doi: 10.1016/j.cmet.2014.11.006 PubMed PMID 25470549 PMCID: PMC4261079.
“Leptin acts via lateral hypothalamic area neurotensin neurons to inhibit orexin neurons by multiple GABA-independent mechanisms”
AUTHORS: Goforth PB, Leinninger GM, Patterson CM, Satin LS, Myers MG Jr.  
PUBLICATION: J Neurosci 2014 Aug 20;34(34):11405-15 doi: 10.1523/JNEUROSCI.5167-13.2014 PubMed PMID 25143620 PMCID:PMC4138347.
“Exposure of mouse embryonic pancreas to metformin enhances the number of pancreatic progenitors”
AUTHORS: Gregg B, Elghazi L, Alejandro EU, Smith MR, Blandino-Rosano M, El-Gabri D, Cras-Méneur C, Bernal-Mizrachi E.  
PUBLICATION: Diabetologia 2014 Dec;57(12):2566-75 doi: 10.1007/s00125-014-3379-5 Epub 2014 Sep 24 PubMed PMID 25249235 PMCID: PMC4417192.
“Inefficient translocation of preproinsulin contributes to pancreatic β cell failure and late-onset diabetes”
AUTHORS: Guo H, Xiong Y, Witkowski P, Cui J, Wang LJ, Sun J, Lara-Lemus R, Haataja L, Hutchison K, Shan SO, Arvan P, Liu M.  
PUBLICATION: J Biol Chem 2014 Jun 6;289(23):16290-302 doi: 10.1074/jbc.M114.562355 Epub 2014 Apr 25 PubMed PMID 24770419 PMCID: PMC4047398.
“Hyperglycemia- and neuropathy-induced changes in mitochondria within sensory nerves”
AUTHORS: Hamid HS, Mervak CM, Münch AE, Robell NJ, Hayes JM, Porzio MT, Singleton JR, Smith AG, Feldman EL, Lentz SI.  
PUBLICATION: Ann Clin Transl Neurol 2014 Oct;1(10):799-812 doi: 10.1002/acn3.119 Epub 2014 Oct 1 PubMed PMID 25493271 PMCID: PMC4241807.
“ERK activation is required for CCK-mediated pancreatic adaptive growth in mice”
AUTHORS: Holtz BJ, Lodewyk KB, Sebolt-Leopold JS, Ernst SA, Williams JA.  
PUBLICATION: Am J Physiol Gastrointest Liver Physiol 2014 Oct 1;307(7):G700-10 doi: 10.1152/ajpgi.00163.2014 Epub 2014 Aug 7 PubMed PMID 25104499 PMCID: PMC4187068.
“A platform technique for growth factor delivery with novel mode of action”
AUTHORS: Kim NH, Cha YH, Kim HS, Lee SE, Huh JK, Kim JK, Kim JM, Ryu JK, Kim HJ, Lee Y, Lee SY, Noh I, Li XY, Weiss SJ, Jahng TA, Yook JI.  
PUBLICATION: Biomaterials 2014 Dec;35(37):9888-96 doi: 10.1016/j.biomaterials.2014.08.005 Epub 2014 Sep 15 PubMed PMID 25218859.
“Independent modulation of contractile performance by cardiac troponin I Ser43 and Ser45 in the dynamic sarcomere”
AUTHORS: Lang SE, Schwank J, Stevenson TK, Jensen MA, Westfall MV.  
PUBLICATION: J Mol Cell Cardiol 2015 Feb;79:264-74 doi: 10.1016/j.yjmcc.2014.11.022 Epub 2014 Dec 3 PubMed PMID 25481661 PMCID: PMC4301988.
“SRA gene knockout protects against diet-induced obesity and improves glucose tolerance”
AUTHORS: Liu S, Sheng L, Miao H, Saunders TL, MacDougald OA, Koenig RJ, Xu B.  
PUBLICATION: J Biol Chem 2014 May 9;289(19):13000-9 doi: 10.1074/jbc.M114.564658 Epub 2014 Mar 27 PubMed PMID 24675075 PMCID: PMC4036315.
“Functional characterization of obesity-associated variants involving the ? and β isoforms of human SH2B1”
AUTHORS: Pearce LR, Joe R, Doche ME, Su HW, Keogh JM, Henning E, Argetsinger LS, ochukova EG, Cline JM, Garg S, Saeed S, Shoelson S, O'Rahilly S, Barroso I, Rui L, Farooqi IS, Carter-Su C.  
PUBLICATION: Endocrinology 2014 Sep;155(9):3219-26 doi: 10.1210/en.2014-1264 Epub 2014 Jun 27 PubMed PMID 24971614 PMCID: PMC4138566.
“Mouse hepatocyte overexpression of NF-κB-inducing kinase (NIK) triggers fatal macrophage-dependent liver injury and fibrosis”
AUTHORS: Shen H, Sheng L, Chen Z, Jiang L, Su H, Yin L, Omary MB, Rui L.  
PUBLICATION: Hepatology 2014 Dec;60(6):2065-76 doi: 10.1002/hep.27348 Epub 2014 Oct 29 PubMed PMID 25088600 PMCID: PMC4245385.
“Differential reduction in corneal nerve fiber length in patients with type 1 or type 2 diabetes mellitus”
AUTHORS: Stem MS, Hussain M, Lentz SI, Raval N, Gardner TW, Pop-Busui R, Shtein RM.  
PUBLICATION: J Diabetes Complications 2014 Sep-Oct;28(5):658-61 doi: 10.1016/j.jdiacomp.2014.06.007 Epub 2014 Jun 17 PubMed PMID 25044236 PMCID: PMC4146399.
“An assay for clogging the ciliary pore complex distinguishes mechanisms of cytosolic and membrane protein entry”
AUTHORS: Takao D, Dishinger JF, Kee HL, Pinskey JM, Allen BL, Verhey KJ.  
PUBLICATION: Curr Biol 2014 Oct 6;24(19):2288-94 doi: 10.1016/j.cub.2014.08.012 Epub 2014 Sep 25 PubMed PMID 25264252 PMCID: PMC4189977.
“Fat depot-specific gene signature and ECM remodeling of Sca1(high) adipose-derived stem cells”
AUTHORS: Tokunaga M, Inoue M, Jiang Y, Barnes RH 2nd, Buchner DA, Chun TH.  
PUBLICATION: Matrix Biol 2014 Jun;36:28-38 doi: 10.1016/j.matbio.2014.03.005 Epub 2014 Apr 13 PubMed PMID 24726953 PMCID: PMC4127346.
“Pten deletion in RIP-Cre neurons protects against type 2 diabetes by activating the anti-inflammatory reflex”
AUTHORS: Wang L, Opland D, Tsai S, Luk CT, Schroer SA, Allison MB, Elia AJ, Furlonger C, Suzuki A, Paige CJ, Mak TW, Winer DA, Myers MG Jr, Woo M.  
PUBLICATION: Nat Med 2014 May;20(5):484-92 doi: 10.1038/nm.3527 Epub 2014 Apr 20 PubMed PMID 24747746.
“A Snail1/Notch1 signalling axis controls embryonic vascular development”
AUTHORS: Wu ZQ, Rowe RG, Lim KC, Lin Y, Willis A, Tang Y, Li XY, Nor JE, Maillard I, Weiss SJ.  
PUBLICATION: Nat Commun 2014 Jun 4;5:3998 doi: 10.1038/ncomms4998 PubMed PMID: 24894949 PMCID: PMC4052376.

2013

“Increased axonal regeneration and swellings in intraepidermal nerve fibers characterize painful phenotypes of diabetic neuropathy”
AUTHORS: Cheng HT, Dauch JR, Porzio MT, Yanik BM, Hsieh W, Smith AG, Singleton JR, Feldman EL.  
PUBLICATION: J Pain 2013 Sep;14(9):941-7 doi: 10.1016/j.jpain.2013.03.005 Epub 2013 May 17 PMID 23685187 PMCID: PMC3994562.
“Proinsulin intermolecular interactions during secretory trafficking in pancreatic β cells”
AUTHORS: Haataja L, Snapp E, Wright J, Liu M, Hardy AB, Wheeler MB, Markwardt ML, Rizzo M, Arvan P.  
PUBLICATION: J Biol Chem 2013 Jan 18;288(3):1896-906 doi: 10.1074/jbc.M112.420018 Epub 2012 Dec 6 PMID 23223446 PMCID: PMC3548498.
“Direct measurements of oscillatory glycolysis in pancreatic islet β-cells using novel fluorescence resonance energy transfer (FRET) biosensors for pyruvate kinase M2 activity”
AUTHORS: Merrins MJ, Van Dyke AR, Mapp AK, Rizzo MA, Satin LS.  
PUBLICATION: J Biol Chem 2013 Nov 15;288(46):33312-22 doi: 10.1074/jbc.M113.508127 Epub 2013 Oct 7 PMID 24100037 PMCID: PMC3829177.
“Adenylyl cyclase 6 mediates the action of cyclic AMP-dependent secretagogues in mouse pancreatic exocrine cells via protein kinase A pathway activation”
AUTHORS: Sabbatini ME1, D'Alecy L, Lentz SI, Tang T, Williams JA.  
PUBLICATION: J Physiol 2013 Aug 1;591(15):3693-707 doi: 10.1113/jphysiol.2012.249698 Epub 2013 Jun 10 PMID 23753526 PMCID: PMC3752451.
“Artificial sweeteners stimulate adipogenesis and suppress lipolysis independently of sweet taste receptors”
AUTHORS: Simon BR, Parlee SD, Learman BS, Mori H, Scheller EL, Cawthorn WP, Ning X, Gallagher K, Tyrberg B, Assadi-Porter FM, Evans CR, MacDougald OA.  
PUBLICATION: J Biol Chem 2013 Nov 8;288(45):32475-89 doi: 10.1074/jbc.M113.514034 Epub 2013 Sep 24 PMID 24068707 PMCID: PMC3820882.
“Phosphorylation of the adaptor protein SH2B1β regulates its ability to enhance growth hormone-dependent macrophage motility”
AUTHORS: Su HW, Lanning NJ, Morris DL, Argetsinger LS, Lumeng CN, Carter-Su C.  
PUBLICATION: J Cell Sci 2013 Apr 15;126(Pt 8):1733-43 doi: 10.1242/jcs.113050 Epub 2013 Feb 26 PMID 23444381 PMCID: PMC3678408.
“Dominant protein interactions that influence the pathogenesis of conformational diseases”
AUTHORS: Wright J, Wang X, Haataja L, Kellogg AP, Lee J, Liu M, Arvan P.  
PUBLICATION: J Clin Invest 2013 Jul;123(7):3124-34 doi: 10.1172/JCI67260 Epub 2013 Jun 3 PMID 23722904 PMCID: PMC3696544.

2012-2010 (Reduced selection)

“Leptin action through hypothalamic nitric oxide synthase-1-expressing neurons controls energy balance”
AUTHORS: Leshan RL, Greenwald-Yarnell M, Patterson CM, Gonzalez IE, Myers MG Jr.  
PUBLICATION: Nat Med 2012 May;18(5):820-3 PMID 22522563 PMCID: PMC3531967.
“Nerve growth factor/p38 signaling increases intraepidermal nerve fiber densities in painful neuropathy of type 2 diabetes”
AUTHORS: Cheng HT, Dauch JR, Hayes JM, Yanik BM, Feldman EL.  
PUBLICATION: Neurobiol Dis 2012 Jan;45(1):280-7 Epub 2011 Aug 18 PMID 21872660 PMCID: PMC3225563.
“Molecular Mapping of the Neural Pathways Linking Leptin to the Neuroendocrine Reproductive Axis”
AUTHORS: Louis GW, Greenwald-Yarnell M, Phillips R, Coolen LM, Lehman MN, Myers MG Jr.  
PUBLICATION: Endocrinology 2011 Jun;152(6):2302-10 Epub 2011 Mar 22 PMID 21427219 PMCID: PMC3100610.
“Transcriptional profiling of diabetic neuropathy in the BKS db/db mouse: a model of type 2 diabetes”
AUTHORS: Pande M, Hur J, Hong Y, Backus C, Hayes JM, Oh SS, Kretzler M, Feldman EL.  
PUBLICATION: Diabetes 2011 Jul;60(7):1981-9 Epub 2011 May 26 PMID 21617178 PMCID: PMC3121428.
“Structural and functional analysis of tomosyn identifies domains important in exocytotic regulation”
AUTHORS: Williams AL, Bielopolski N, Meroz D, Lam AD, Passmore DR, Ben-Tal N, Ernst SA, Ashery U, Stuenkel EL.  
PUBLICATION: J Biol Chem 2011 Apr 22;286(16):14542-53 Epub 2011 Feb 17 PMID 21330375 PMCID: PMC3077652.
“p38 mediates mechanical allodynia in a mouse model of type 2 diabetes”
AUTHORS: Cheng HT, Dauch JR, Oh SS, Hayes JM, Hong Y, Feldman EL.  
PUBLICATION: Mol Pain 2010 May 19;6:28 PMID 20482876 PMCID: PMC2881061.
“CCK-independent mTORC1 activation during dietary protein-induced exocrine pancreas growth”
AUTHORS: Crozier SJ, Sans MD, Wang JY, Lentz SI, Ernst SA, Williams JA.  
PUBLICATION: Am J Physiol Gastrointest Liver Physiol 2010 Nov;299(5):G1154-63 Epub 2010 Aug 26 PMID 20798356 PMCID: PMC2993171 Edwards JL, Quattrini A, Lentz SI, Figueroa-Romero C, Cerri F, Backus C, Hong Y, Feldman EL Diabetes regulates mitochondrial biogenesis and fission in mouse neurons Diabetologia.
“Misfolded proinsulin affects bystander proinsulin in neonatal diabetes”
AUTHORS: Hodish I, Liu M, Rajpal G, Larkin D, Holz RW, Adams A, Liu L, Arvan P.  
PUBLICATION: J Biol Chem 2010 Jan 1;285(1):685-94 Epub 2009 Oct 30 PMID 19880509 PMCID: PMC2804216.
“Mapping dynamic protein interactions to insulin secretory granule behavior with TIRF-FRET”
AUTHORS: Lam AD, Ismail S, Wu R, Yizhar O, Passmore DR, Ernst SA, Stuenkel EL.  
PUBLICATION: Biophys J 2010 Aug 9;99(4):1311-20 PMID 20713017 PMCID: PMC2920663.
“Ventral tegmental area leptin receptor neurons specifically project to and regulate cocaine- and amphetamine-regulated transcript neurons of the extended central amygdala”
AUTHORS: Leshan RL, Opland DM, Louis GW, Leinninger GM, Patterson CM, Rhodes CJ, Müenzberg H, Myers MG Jr.  
PUBLICATION: J Neurosci 2010 Apr 21;30(16):5713-23 PMID 20410123 PMCID: PMC2864009.
“Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain”
AUTHORS: Wicksteed B, Brissova M, Yan W, Opland DM, Plank JL, Reinert RB, Dickson LM, Tamarina NA, Philipson LH, Shostak A, Bernal-Mizrachi E, Elghazi L, Roe MW, Labosky PA, Myers MG Jr, Gannon M, Powers AC, Dempsey PJ.  
PUBLICATION: Diabetes 2010 Dec;59(12):3090-8 Epub 2010 Aug 29 PMID 20802254 PMCID: PMC2992770.