Michigan Diabetes Research Center: Molecular Genetics Core


The Molecular Genetics Core provides services related to the application of genetic methodologies to research related to diabetes:

Generation of targeted genetic mouse models, using CRISPR/Cas9 system in mouse or rat embryos:
  • Gene edited alleles
  • Knockout alleles
  • loxP-flanked alleles
  • Knock-in alleles (gene insertions, e.g., cre and Flp recombinases, rtTA (“TET-on”), GFP)
  • Cost includes design, construct assembly, embryo injection costs, and screening of potential founders.
  • Application of CRISPR-Cas9 technology in specific genetic backgrounds is available on request, at extra cost.
Generation of specialty viral vectors:
  • Constitutive or cre-inducible AAVs expressing transgenes of interest
  • Cost includes design and construct assembly. Viral production costs are paid directly to the Viral Vector Core by user. ALL costs may be waived for reagents likely to be of general interest, providing that PI is willing to allow distribution to other MDRC members following initial testing.
Specialty viral reagents:
  • Defective pseudotyped rabies viruses for tract-tracing, including AAV helper viruses
  • A panel of general interest cre-inducible AAVs (for list, click here)
  • Under development: AAV-driven CRISPR/Cas9 reagents for gene ablation in animals
Specialty Mouse models

Cost of services:

Knock-in Rate
$9,781 *
Edit/Knock-out Rate
$8,281 *
Flox Rate
$9,991 *
  • * Animal housing/shipping fees are not included in these rates and will be billed to the client upon mouse transfer
  • * The University of Michigan indirect cost rate of 29.0% will be applied to all requests from external, non-UM clients
  • * A credit card fee of 3% will be applied to any requests from external, non-UM clients paying with a credit card ($10k or less).

Service Agreement/Application

For more information contact:

David P. Olson, MD, PhD
MDRC Molecular Genetics Lab
Brehm Tower Room 6442

Key Personnel

David P. Olson, MD, PhD, Core Director
dpolson@med.umich.edu, 734-232-8205
Thomas Lanigan, PhD, Co-Investigator
lanigant@med.umich.edu, 734-764-5201
Huira Kopera, PhD, Research Laboratory Specialist Intermediate, Vector Core Assistant Director and AAV specialist
Dennis Larkin, BS, Research Laboratory Specialist
dlarkin@med.umich.edu, 734-936-5505
Qing Zhu, BS, Research Associate
qinzhu@med.umich.edu, 734-647-9538
Julianna White, Research Assistant
julianwh@med.umich.edu, 734-647-9538


MDRC Molecular Genetics Core, Brehm Tower
1000 Wall Street
Room No. 6442
Telephone: 734-647-9538